Opposing enzymes cooperate in ERAD

Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins.

The serpinopathies are a family of diseases characterized by the accumulation of ordered polymers of mutant protein within the endoplasmic reticulum. They are a diverse group including alpha(1)-antitrypsin deficiency and the inherited dementia familial encephalopathy with neuroserpin inclusion bodies or FENIB. We have used transient transfection of COS7 cells and mouse embryonic fibroblasts, PC...

Sweet bays of ERAD.

Proteins that improperly mature in the endoplasmic reticulum (ER) are dislocated to the cytoplasm for proteasome-mediated destruction. A recent study provides insight into the incompletely understood processes for selection and targeting of aberrant proteins for ER-associated protein degradation. The identification of the ER chaperones GRP94 and BiP as binding partners for the mannose-binding p...

Ultra- Relativistic Solitons with Opposing Behaviors in Photon Gas Plasma

We have studied the formation of relativistic solitary waves due to nonlinearinteraction of strong electromagnetic wave with the plasma wave. Here, our plasma isrelativistic both in temperature and in streaming speed. A set of equations consisting ofscalar and vector potentials together with a third order equation for the enthalpy inphoton gas plasma is obtained analytic...

ERAD substrates: which way out?

Global folding of polypeptides entering the endoplasmic reticulum (ER) starts as soon as they emerge from the narrow Sec61 translocon. Attainment of the native structure can take from several minutes to hours, depending on the gene product. Until then, non-native folding intermediates must be protected from molecular chaperones that recognize misfolded determinants and could prematurely interru...

To Cooperate or Not to Cooperate